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Year : 2021  |  Volume : 1  |  Issue : 1  |  Page : 26-33

Dosimetric feasibility and clinical outcome of image-guided interstitial brachytherapy using two different fractionation schedule in carcinoma cervix

Department of Radiotherapy, Medical College & Hospital Kolkata, Kolkata, West Bengal, India

Correspondence Address:
Dr. Janmenjoy Mondal
Department of Radiotherapy, Medical College & Hospital Kolkata, Room no. 13, 88 College Street, Kolkata 700073, West Bengal.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bjoc.bjoc_16_21

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Methods and Material: Overall, 60 patients were accrued between 2014 and 2017 and treated with ISBT by using Syed–Neblett Template by iridium 192 with Gamma Med plus HDR after the loader unit. They were allotted in two arms (n = 30) and received nine Gy ×2# and 7 Gy ×3 # respectively. All patients received 50Gy/25# whole pelvis EBRT by Theratron 780C. Coverage Index (CI), dose homogeneity index (DHI), overdose index (OI), dose non-uniformity ratio (DNR), D90Target, and 2cc EQD2 of OARs were calculated and correlated with toxicity, locoregional control, and survival. Statistical Analysis Used: Unpaired t-test and chi-square test were used to compare numerical and categorical variables, using IBM SPSS, V23. PFS and OS were calculated by using Kaplan–Meier analysis, and a log-rank test was used for comparison. A p-value ≤ 0.05 was considered significant. Results: Mean EQD2 for bladder (77.33 vs. 80.24 Gy) and rectum (69.12 vs. 69.87) along with D90 (9.12Gy vs. 7.20Gy) were comparable. With a median follow-up period of 38 months, three-year local control rate was 56.6% vs. 46.60% (P = 0.72) and three-year OS was also similar, 83% vs. 80% (p=.8). Dosimetric parameters and toxicity profile between two groups were comparable. Conclusions: 9Gy ×2 # is a reasonably good alternative for treating the locally advanced carcinoma cervix.

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