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Year : 2022  |  Volume : 2  |  Issue : 1  |  Page : 11-16

Clinico-pathological Factors Determining Recurrence in Phyllodes Tumor of the Breast: The 25-Year Experience at a Tertiary Cancer Center in Eastern India

1 Imperial College London Healthcare NHS Trust UK, London, UK; Department of Surgical Oncology, SGCCRI, Kolkata, India
2 Department of Surgical Oncology, SGCCRI, Kolkata, India
3 Department of Pathology, SGCCRI, Kolkata, India

Correspondence Address:
Baijaeek Sain
Specialty Trainee ST-2 and Clinical Fellow, Dept. of Trauma & Orthopaedics Surgery, St. Mary’s Hospital, Imperial College Healthcare NHS Trust, London
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bjoc.bjoc_10_22

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Background: Phyllodes tumour(PT) of the breast are rare fibroepithelial tumours that are generally more prone to recurrence. Aims and objective: The study aimed to assess the clinico-pathological features, diagnostic modalities and therapeutic interventions with their outcomes leading to recurrence in Phyllodes tumour of the breast. Materials and Methods: A retrospective cohort and observational study which entailed clinico-pathological data of patients who were previously diagnosed or presented with Phyllodes tumour of the breast between 1996 and 2021 were analysed. Data included- total number of patients diagnosed with Phyllodes tumour of the breast, age, type of tumour on initial presentation or biopsy, side, size, therapeutic interventions carried out- surgery(mastectomy or lumpectomy) and adjuvant radiotherapy, final biopsy type, recurrence, type of recurrence and time to recurrence. Results: We analysed a total of 87 patients who were pathologically proven to have PT and 46 patients(52.87%) were found to have recurrence. All patients were recorded to be in the female gender only with a mean age at diagnosis of 39 years (range 15–70). Age <40 years had the highest incidence of recurrence of 56.82%(n = 25) followed by age>40 years with 48.84%(n = 21). 55.4% patients presented with primary phylloides and 44.6% had recurrent phylloides at presentation. Average time of local recurrence from the time of completion of treatment were 13.8 months whereas for systemic recurrence it were 15.29 months. Surgery(mastectomy/lumpectomy) with regard to local recurrence was the major determinant for recurrence followed by adjuvant radiation. (P <0.05)Conclusion: Patients who received adjuvant radiation had minimal recurrence. Patients who were found to have malignant type of biopsy on initial diagnosis(triple assessment) had more incidence and were prone to systemic recurrence over local recurrence. Surgery again played a determining factor leading to increased rate of local recurrence following lumpectomy over mastectomy.

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