• Users Online: 104
  • Print this page
  • Email this page
ORIGINAL ARTICLES
Year : 2021  |  Volume : 1  |  Issue : 1  |  Page : 19-25

Demographic profile and clinicopathological patterns of colorectal cancer in subhimalayan North India


1 Department of Radiation Oncology and Nuclear Medicine, Dr Rajendra Prasad Government Medical College, Kangra at Tanda, Himachal Pradesh, India
2 Department of Pathology, Dr Rajendra Prasad Government Medical College, Kangra at Tanda, Himachal Pradesh, India

Correspondence Address:
Dr. Muninder Negi
Department of Radiation Oncology and Nuclear Medicine, Dr Rajendra Prasad Government Medical College, Ground Floor, Super Speciality Block, Kangra at Tanda 176001, Himachal Pradesh.
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bjoc.bjoc_18_21

Rights and Permissions

Background: Despite colorectal carcinoma being one of the common cancers with an increasing incidence over the past few decades, there are only a few studies that have assessed its demographic, clinical, and pathological profile in the north Indian population. Objective: To assess the demographic and clinicopathological patterns of colorectal cancer (CRC) among patients in the subhimalayan region of North IndiaMaterials and Methods: This retrospective cross-sectional study analyzed the data of 244 patients with CRC who were referred to a state-owned medical college in Himachal Pradesh, India, between January 2016 and April 2020. Demographic, clinical, and pathological information was extracted from patient record files. Results: The mean age of patients in the study was 51.2 years, with an age range from 19 to 81 years. Approximately 48% of the patients were aged between 40 and 60 years, 15% were younger than 40 years, 56% of the patients were male, and 44% of the patients were female. Rectal bleeding (~46%), change in bowel habits (~41%), and abdominal pain (39%) were the common clinical symptoms. Overall, 73% of the patients were diagnosed at a mean duration of five months after the onset of their symptoms, and approximately 36% of the patients were in stage II and 48% were in stage III at the time of diagnosis. Colon carcinoma accounted for 76% of the patients, 17% had rectal carcinoma, 5% had carcinoma of recto-sigmoid, and 2% of the patients were diagnosed with ano-rectal carcinoma. Histopathologically ~ 81% patients had adenocarinoma, 14% had mucous carcinoma, 3% had signet ring carcinoma, and 2% had NET. Conclusions: In the subhimalayan region in North India, CRC has a higher male gender predominance, with a substantial number of patients younger than 40 years. Most of the cases are diagnosed after a mean duration of five months of the symptoms. Colon carcinomas are more common than rectal carcinomas, with left-sided colon carcinomas being more common than right-sided colon carcinomas. The majority of tumors are adenocarcinomas, whereas mucinous carcinomas are less common and signet ring carcinomas are rare. A greater number of patients with right-sided colon carcinomas have a higher stage and a more aggressive tumor grade at the time of diagnosis. The study also shows that there is a need to be more vigilant for colorectal carcinoma in patients with lower GIT symptoms and it lays emphasis on a colorectal screening program in such patients, to enable early detection of this tumor.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed206    
    Printed2    
    Emailed0    
    PDF Downloaded39    
    Comments [Add]    

Recommend this journal